Subtype-specific therapy for autoimmune neuropathies?

Subtype-specific therapy for autoimmune neuropathies?

Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are the most common autoimmune neuropathies. In both disorders, different variants have been described, reflecting the types of axons that are affected (motor and/or sensory), the nature of the injury (axonal vs demyelinating), and the response to treatment. Because most patients respond to therapies that...

AutoiMMune/inflAMMAtory optic neuropAthies

InTRoDUCTIon Inflammatory, demyelinating optic neuritis is one of the most common optic neuropathies in young adults. It occurs idiopathically, or in association with multiple sclerosis, and follows a typical course of progressing visual dysfunction often with pain for one – two weeks, followed by significant resolution over the next few weeks. Due to the characteristic presentation and frequen...

Autoimmune neuropathies and treatment with intravenous immunoglobulins

Optimizing IgG Therapy in Chronic Autoimmune Neuropathies: A Hypothesis Driven Approach

Prolonged intravenous immunoglobulin (IVIG) therapy is used for the chronic autoimmune neuropathies chronic idiopathic demyelinating polyneuropathy and multifocal motor neuropathy, but the doses and treatment intervals are usually chosen empirically due to a paucity of data from dose-response studies. Recent studies of the electrophysiology and immunology of these diseases suggest that antibody...

cyclosporine therapy for autoimmune hepatitis in children

background: the current immunosuppressive treatment of patients with autoimmune hepatitis (aih) consists of prednisolone and azathioprine. high doses of prednisolone used for disease remission are not universally effective and have serious adverse effects. some authors have provided evidence of aih therapy in children and adults with cyclosporine (neoral) should corticosteroid therapy become in...